Thermo Fisher Scientific Phospho-ATR (Thr1989) Recombinant Rabbit Monoclonal Antibody (PS01-18)
Phospho-ATR (Thr1989) 특이적 재조합 토끼 단클론 항체로, DNA 손상 반응 연구에 적합. Western blot과 면역세포염색(ICC/IF)에 검증됨. 고순도 Protein A 정제, 안정적 액상 포맷. 인간 시료 반응성, 비마우스·비랫 교차 반응.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PS01-18 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding Thr1989 of human ATR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2937394 |
Product Specific Information
- Predicted band size: 301 kDa
- Positive Control: HeLa cell lysate; HeLa treated with 4 mM Hydroxyurea for 20 hours
- Subcellular Location: Chromosome, Nucleus
- Sequence Similarities: No cross-reactivity with Mouse and Rat
- Tissue Specificity: Ubiquitous, highest in testis. Isoform 2 found in pancreas, placenta, and liver but not in heart, testis, or ovary.
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor that activates cell cycle checkpoint signaling upon DNA stress. It phosphorylates and activates several proteins involved in the inhibition of DNA replication and mitosis, and promotes DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene cause Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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