Thermo Fisher Scientific KIAA1598 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

SHTN1 is a protein-coding gene involved in generating internal asymmetric signals required for neuronal polarization and neurite outgrowth. It mediates netrin-1-induced F-actin–substrate coupling ("clutch engagement") within the axon growth cone through activation of CDC42, RAC1, and PAK1-dependent signaling pathways, converting F-actin retrograde flow into traction forces associated with filopodium extension and axon outgrowth.

SHTN1 also regulates cytoskeletal organization by controlling the subcellular localization of PI3K activity at the axonal growth cone and promotes regenerative neurite outgrowth. In the developing cortex, it cooperates with KIF20B to facilitate the transition from multipolar to bipolar stages and the radial migration of cortical neurons toward the superficial neocortex layer. It is involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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