Thermo Fisher Scientific Phospho-ALK (Tyr1604) Polyclonal Antibody
ALK 단백질의 Tyr1604 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 유효하며, 인간·마우스·래트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific Phospho-ALK (Tyr1604) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALK (Accession Q9UM73), corresponding to amino acid residues around phosphorylated Tyr1604 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816040 |
Product Specific Information
This antibody detects endogenous levels of ALK only when phosphorylated at Tyr1604.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement often results in a fusion gene between ALK and nucleophosmin (NPM), forming the oncogenic NPM-ALK fusion protein. ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK. It plays a crucial role in neuronal development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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