Thermo Fisher Scientific Human STK3 (MST2), GST Tag Recombinant Protein
Human STK3 (MST2) 단백질로, GST 태그가 부착된 재조합 단백질입니다. Insect cell에서 발현되었으며, kinase assay에 사용 가능합니다. Hippo 신호 경로 연구 및 세포 증식·사멸 조절 연구에 적합합니다. -80°C에서 보관하며 동결·해동 반복을 피해야 합니다.
- 카탈로그번호
- PV4806
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human STK3 (MST2), GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | Full length |
| Tag | GST-tag |
| Molecular Weight | 85.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 50% glycerol, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
- For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
- Never store kinase diluted.
- Properly stored at -80°C, guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Target Information
STK3 (MST2) is a member of the STE kinase family acting upstream of MAP kinase signaling pathways. It is activated by proapoptotic stimuli such as staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase that, after caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.
It plays a key role in the Hippo signaling pathway, regulating organ size and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, with SAV1, activate LATS1/2 and MOB1, which then phosphorylate and inactivate YAP1 and WWTR1/TAZ. This phosphorylation prevents YAP1 nuclear translocation, controlling genes related to proliferation, cell death, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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