Thermo Fisher Scientific Human STK3 (MST2), GST Tag Recombinant Protein

Thermo Fisher Scientific Human STK3 (MST2), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: [References not provided]

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
• For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.

Protein Form: Full Length

Target Information

STK3 (MST2) is a member of the STE kinase family acting upstream of MAP kinase signaling pathways. It is activated by proapoptotic stimuli such as staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase that, after caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.
It plays a key role in the Hippo signaling pathway, regulating organ size and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, with SAV1, activate LATS1/2 and MOB1, which then phosphorylate and inactivate YAP1 and WWTR1/TAZ. This phosphorylation prevents YAP1 nuclear translocation, controlling genes related to proliferation, cell death, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.