Thermo Fisher Scientific EPCAM Monoclonal Antibody (OTI2A3), TrueMAB
인간 EPCAM을 인식하는 Mouse IgG1 단클론 항체로 Western Blot, IHC, ICC 등 다양한 응용에 적합. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer에 보존. Ep-CAM 관련 암 및 상피세포 연구용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A3 |
| Immunogen | Full-length human recombinant EPCAM protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial cells. It functions as a calcium-independent homotypic adhesion molecule and influences cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E. Ep-CAM-mediated adhesions negatively regulate cadherin-based adhesions, affecting epithelial differentiation and growth. Overexpression is associated with increased epithelial proliferation and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on basolateral surfaces of simple epithelia and many carcinoma types, and can distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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