Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI15G8)
ZEB2 단백질을 인식하는 Mouse 모노클로날 항체로 Western blot과 IHC(Paraffin)에 적합합니다. 고순도의 Affinity Chromatography 정제 항체이며, PBS/BSA/glycerol buffer에 보존됩니다. ZEB2 관련 세포 신호 및 암 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15G8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of ZEB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725694 |
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Similar to ZEB1, ZEB2 inhibits E-cadherin gene transcription and induces epithelial-mesenchymal transition (EMT), a process regulating cell migration during embryonic development and wound healing. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting a role in tumor progression. It is frequently observed in the cytoplasm of various cancers, indicating regulation of its localization. Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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