Thermo Fisher Scientific Phospho-Tau protein (Ser519) Polyclonal Antibody
Phospho-Tau (Ser519) 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 생쥐, 랫드에 반응합니다. Western blot, IHC, ICC, ELISA 등에 사용 가능하며, Protein A 정제 방식으로 고순도 확보. 신경퇴행성 질환 연구용으로 적합.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Tau protein around the phosphorylation site of Ser519 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between them. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.
Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms aid in stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease (AD) brains. This modification impairs Tau’s microtubule-binding ability, leading to destabilization and neuronal degeneration.
Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also observed in other neurodegenerative conditions such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific CXCR4 Polyclonal Antibody
551,400원
Thermo Fisher Scientific
Thermo Fisher Scientific Phospho-gp130 (Ser782) Polyclonal Antibody
569,000원
Thermo Fisher Scientific
Thermo Fisher Scientific Phospho-Tau protein (Ser519) Polyclonal Antibody
569,000원
Thermo Fisher Scientific
Thermo Fisher Scientific Phospho-Tau protein (Ser733) Polyclonal Antibody
569,000원
Thermo Fisher Scientific
Thermo Fisher Scientific Phospho-Tau protein (Thr522) Polyclonal Antibody
569,000원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|