Thermo Fisher Scientific GAB1 Polyclonal Antibody
Rabbit polyclonal antibody targeting GAB1 protein (aa 644–694). Validated for Western blot at 1:1,000 dilution. Supplied as unconjugated liquid at 0.40 mg/mL. Recommended storage at 4°C, shipped on wet ice. For research use only.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 644–694 of GAB1 (UniProt ID: Q13480-1, NCBI Taxonomy ID: 9606) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.40 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Gab1 is a 115 kDa multiple docking protein essential for cellular growth, transformation, and apoptosis.
It can be phosphorylated by multiple receptor tyrosine kinases (RTKs), including:
- Insulin receptor (IR)
- Platelet-derived growth factor receptor beta (PDGFRβ)
- Hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met)
- Epidermal growth factor receptor (EGFR)
Gab1 undergoes tyrosine phosphorylation at least at 16 sites, serving as binding sites for PI3K, Grb2, PLCγ1, Nck, and SHP2.
Phosphorylation on tyrosines 627 and 659 is critical for SHP2 binding and activation of the ERK/MAPK pathway in response to EGF.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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