Thermo Fisher Scientific PICK1 Polyclonal Antibody
PICK1 단백질을 인식하는 염소 폴리클로날 항체로, Western blot과 IHC(파라핀 절편)에 적합합니다. 인간 및 생쥐 반응성이 있으며, TBS 완충액(0.5% BSA) 내 액상 형태로 제공됩니다. 단백질 수송 및 시냅스 단백질 상호작용 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HYNKLQADPKQ) corresponding to the internal amino acids of PICK1 (aa 100–110) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10985428 |
Product Specific Information
- Predicted to react with bovine, canine, human, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization.
PICK1 (Protein Interacting with Protein Kinase C) is a synaptic PDZ domain protein containing a coiled-coil and acidic domain.
PICK1 functions as a targeting and transport protein and interacts with PKCα, AMPA-type glutamate receptors, and other membrane receptors via its PDZ domain.
The interaction with PKCα depends on kinase activation and directs activated PKCα to membrane-anchored GluR2.
Once phosphorylated, GluR2 is released and transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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