Thermo Fisher Scientific EDA2R Polyclonal Antibody

Applications and Tested Dilution

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
CQENEYWDQWG RCVTCQRCGP GQELSKDCGY GEGGDAYCTA CPPRRYKSSW GHHKCQSCIT CAVINRVQKV NCTATS

Highest antigen sequence identity to the following orthologs:

• Mouse: 86%
• Rat: 88%

Target Information

X-linked ectodysplasin-A2 receptor (XEDAR) is a member of the tumor necrosis factor receptor family, highly expressed during embryonic development and binds to ectodysplasin-A2 (EDA-A2). Two isoforms, XEDAR-s and XEDAR-L, differ by a 21-amino acid region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain; both act mainly through TRAF3 and TRAF6 to activate NF-κB and JNK pathways. XEDAR-transfected cells treated with EDA-A2 form a secondary complex containing FADD, caspase-8, and caspase-10, leading to activation of caspase-8 and caspase-3, and ultimately apoptosis. The EDA-A2-induced apoptosis depends on caspase-9 activation, as inhibitors of caspase-8 block apoptosis following EDA-A2 treatment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.