Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI1B1), Biotin, TrueMAB
STAT4 단백질을 타깃으로 하는 Biotin 결합 단클론 항체입니다. ELISA 및 Luminex 분석에 적합하며, Human 시료에 반응합니다. 고순도의 Affinity chromatography 정제 방식으로 제조되었으며, PBS/BSA/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA (ELISA) | 1:250–1:1,000 |
| Luminex (LUM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Full length human recombinant protein of human STAT4 produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homo- or heterodimers with related STAT family members. Phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which plays a critical role in T-cell independent induction of IFN-gamma and Th1 response development. STAT4-deficient mice show impaired IL-12-induced Th1 development and enhanced Th2 cell development. In response to viral infection, IFN-a/b activation of STAT4 is required for IFN-gamma production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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