Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI2F3), Biotin, TrueMAB
STAT4 단백질을 표적으로 하는 Biotin 결합 단클론 항체로, ELISA 및 Luminex 등 다양한 분석에 적합. 인간 STAT4 재조합 단백질을 면역원으로 제작. 고순도 Affinity chromatography 정제, 안정적 PBS/BSA/glycerol buffer 보존. 연구용으로만 사용 가능.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:250–1:1,000
Luminex (LUM)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F3 |
| Immunogen | Full length human recombinant STAT4 protein produced in HEK293T cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
STAT4 was originally identified using degenerate primers complementary to conserved regions of other STAT proteins. The STAT4 protein shares high similarity with STAT1 (52%) and STAT3 (47%). It can be tyrosine phosphorylated by Jak1 or Jak2, forming homo- and heterodimers with related STAT family members. Phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is mainly found in the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is essential for IFN-gamma induction and Th1 cell development during immune responses against bacterial and parasitic infections. STAT4-deficient mice show impaired Th1 and enhanced Th2 development. Additionally, IFN-α/β activation of STAT4 is required for IFN-γ production during viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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