Thermo Fisher Scientific RBFOX3 Monoclonal Antibody (OTI2E5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RNA recognition motif (RRM) domain.
Localized to both the nucleus and cytoplasm, Fox-3 regulates alternative splicing events. The gene encoding Fox-3 is located on human chromosome 17, which contains over 1,200 genes and represents about 2.5% of the human genome.
Chromosome 17 also harbors two key tumor suppressor genes — p53 and BRCA1 — both essential for DNA repair and maintaining genomic integrity. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome, while BRCA1 mutations are linked to early-onset breast and ovarian cancers, as well as cancers of the colon, prostate, and fallopian tubes.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.