Thermo Fisher Scientific NIK Monoclonal Antibody (2G2B4)
인간 NIK 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, WB, IHC, Flow Cytometry, ELISA에 적합. 고순도 Protein G 정제, 액상 형태로 제공되며 연구용으로만 사용. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific NIK Monoclonal Antibody (2G2B4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G2B4 |
| Immunogen | Purified recombinant fragment of human MAP3K14 (AA: 769–947) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090899 |
Target Information
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKα) and IKBKB (IKKβ), which in turn phosphorylate IκB-α, releasing NF-κB and leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-κB activity. It shares sequence similarity with several other MAPKK kinases and participates in an NF-κB-inducing signaling cascade common to receptors of the TNF/NGF family and the interleukin-1 type-I receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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