Thermo Fisher Scientific Rubicon Polyclonal Antibody
인간 Rubicon 단백질을 인식하는 토끼 유래 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 합성 펩타이드 면역원 기반으로 제작되었으며, 액상 형태로 1 mg/mL 농도, PBS+50% 글리세롤 버퍼에 보존됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Rubicon Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RUBCN (Accession Q92622), corresponding to amino acid residues R193–E243 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900489 |
Product Specific Information
Antibody detects endogenous levels of total Rubicon.
Target Information
Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon enhances autophagy, while knockdown of ATG14L causes a defect in autophagosome formation. Rubicon functions as part of a Beclin-1–PIK3C3-containing autophagy complex and acts as a positive regulator of the NADPH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NADPH oxidase complex, leading to reactive oxygen species production and inflammatory cytokine release.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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