Thermo Fisher Scientific Phospho-BAP1 (Ser592) Polyclonal Antibody
Phospho-BAP1 (Ser592) 폴리클로날 항체로, 인간 및 랫트 시료에서 BAP1 단백질의 Ser592 인산화 상태를 검출. IHC, ICC/IF, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제 및 안정적 액상 형태로 제공.
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Thermo Fisher Scientific Phospho-BAP1 (Ser592) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BRCA1-associated protein-1 (BAP1) interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), which are thiol proteases that catalyze proteolytic processing of ubiquitin.
BAP1 contains an acidic region, a highly charged C-terminal region, and two putative nuclear localization signals. It associates with BRCA1 in vivo and shares overlapping subnuclear localization patterns.
BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with a 4.8-kb transcript expressed exclusively in testis.
BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21.3, a region frequently deleted in breast and lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines, suggesting that BAP1 functions as a tumor suppressor gene in the BRCA1 growth control pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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