Thermo Fisher Scientific MCM3 Monoclonal Antibody (3E1)
인간 MCM3 단백질을 인식하는 Mouse IgG2b 단일클론 항체. Western blot, ICC/IF, ELISA에 적합. 액상 형태로 제공되며 PBS buffer에 보존제 없이 저장. 친화성 크로마토그래피로 정제된 연구용 항체.
- 카탈로그번호
- H00004172-M03
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E1 |
| Immunogen | MCM3 (NP_002379, 699–808 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AKDGDSYDPY DFSDTEEEMP QVHTPKTADS QETKESQKVE LSESRLKAFK VALLDVFREA HAQSIGMNRL TESINRDSEE PFSSVEIQAA LSKMQDDNQV MVSEGIIFLI
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The MCM2–7 hexameric complex is a key component of the pre-replication complex (pre_RC) and participates in replication fork formation and recruitment of other DNA replication-related proteins.
MCM3 interacts directly with MCM5/CDC46 and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. Acetylation inhibits initiation of DNA replication and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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