Thermo Fisher Scientific LAMTOR1 Polyclonal Antibody
LAMTOR1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상형 항체이며, PBS와 50% 글리세롤에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LAMTOR1 (Accession Q6IAA8), corresponding to amino acid residues E10–K60 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900127 |
Product Specific Information
Antibody detects endogenous levels of total LAMTOR1.
Target Information
The Ragulator complex is comprised of three proteins — C11orf59, ROBLD3, and MAPKSP1 — which target mTORC1 to lysosomal surfaces. This normal endosomal trafficking is exploited by certain viruses, including coronavirus, which shows increased replication when C11orf59 is interfered with.
C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and dysregulation of the normal mTOR pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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