Thermo Fisher Scientific LAP2 Polyclonal Antibody
LAP2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/50% glycerol에 보관하며, -20°C에서 안정적으로 저장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TMPO (Accession P42166), corresponding to amino acid residues P402–P452 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900130 |
Product Specific Information
Antibody detects endogenous levels of total LAP2 alpha.
Target Information
In eukaryotic cells, the nuclear envelope consists of inner and outer membranes that define the border between the nucleus and cytoplasm. The inner membrane is supported by the nuclear lamina, composed of lamins, which attach to the membrane via Lamin Associated Polypeptides (LAPs). LAP1A, 1B, and 1C share high sequence homology, while LAP2 is distinct and binds only lamin B1. LAP2 also binds to chromosomes, and its phosphorylation during mitosis inhibits this binding, indicating an important role in nuclear envelope reassembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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