Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI9E8), TrueMAB

Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI9E8), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits may serve as plasma carrier molecules.

Platelet factor XIII is comprised only of 2 A subunits, identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot.

Factor XIII also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit alone

These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.