Thermo Fisher Scientific BEND3 Polyclonal Antibody
Human BEND3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:500–1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. Transcriptional repressor 연구용으로 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BEND3. Recombinant protein control fragment (Product #RP-90911) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638531 |
Product Specific Information
Immunogen sequence:
CLPQLNDFFS RFWAQREMED SQPSGQVASF FEAEQVDPGH FLDNKDQEEA LSLDRSSTIA SDHVVDTQDL TEFLDEASSP GEFAVFLLHR LFPELFDHRK LGEQYSCYGD GGKQELDPQR LQIIRNYTEI YFPD
- Highest antigen sequence identity to orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription.
The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909).
Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites.
Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). [UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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