Thermo Fisher Scientific PKP2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 578-837 of human PKP2 (NP_001005242.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PKP2,uniProtId:Q99959-1,ncbiNodeId:9606,antigenRange:578-837,antigenLength:881,antigenImageFileName:PA5-110175_PKP2_Q99959-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110175_PKP2_Q99959-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855586

Product Specific Information

Immunogen sequence: LPEKYSQNIY IQNRNIQTDN NKSIGCFGSR SRKVKEQYQD VPMPEEKSNP KGVEWLWHSI VIRMYLSLIA KSVRNYTQEA SLGALQNLTA GSGPMPTSVA QTVVQKESGL QHTRKMLHVG DPSVKKTAIS LLRNLSRNLS LQNEIAKETL PDLVSIIPDT VPSTDLLIET TASACYTLNN IIQNSYQNAR DLLNTGGIQK IMAISAGDAY ASNKASKAAS VLLYSLWAHT ELHHAYKKAQ FKKTDFVNSR TAKAYHSLKD

Target Information

Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.