Thermo Fisher Scientific PKP2 Polyclonal Antibody
PKP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 578–837 of human PKP2 (NP_001005242.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855586 |
Product Specific Information
Immunogen sequence:
LPEKYSQNIY IQNRNIQTDN NKSIGCFGSR SRKVKEQYQD VPMPEEKSNP KGVEWLWHSI VIRMYLSLIA KSVRNYTQEA SLGALQNLTA GSGPMPTSVA QTVVQKESGL QHTRKMLHVG DPSVKKTAIS LLRNLSRNLS LQNEIAKETL PDLVSIIPDT VPSTDLLIET TASACYTLNN IIQNSYQNAR DLLNTGGIQK IMAISAGDAY ASNKASKAAS VLLYSLWAHT ELHHAYKKAQ FKKTDFVNSR TAKAYHSLKD
Target Information
Plakophilins 1–4 (PKP1–4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments.
These proteins contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes, which are cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress.
Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration.
Plakophilin 2 is essential for desmosome assembly and acts as a morphogenic factor and architectural component of the heart.
Plakophilin 4 regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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