Thermo Fisher Scientific PIWIL2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 398-652 of mouse PIWIL2 (Q8CDG1) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIWIL2,uniProtId:Q8CDG1-1,ncbiNodeId:10090,antigenRange:398-652,antigenLength:971,antigenImageFileName:PA5-110174_PIWIL2_Q8CDG1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110174_PIWIL2_Q8CDG1-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.18 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855585

Product Specific Information

Immunogen sequence: QNKEHFQDEC SKLLVGSIVI TRYNNRTYRI DDVDWNKTPK DSFVMSDGKE ITFLEYYSKN YGITVKEDDQ PLLIHRPSER QNNHGMLLKG EILLLPELSF MTGIPEKMKK DFRAMKDLTQ QINLSPKQHH GALECLLQRI SQNETASNEL TRWGLSLHKD VHKIEGRLLP MERINLRNTS FVTSEDLNWV KEVTRDASIL TIPMHFWALF YPKRAMDQAR ELVNMLEKIA GPIGMRISPP AWVELKDDRI ETYIR

Target Information

The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.