Thermo Fisher Scientific GALNT4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GALNT4.

Target Information

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes.
GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins.
They are characterized by:

• N-terminal transmembrane domain
• Stem region
• Lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif
• C-terminal ricin/lectin-like domain

GalNAc-Ts have different but overlapping substrate specificities and expression patterns.
In vitro, the encoded protein can complement other GalNAc-Ts in complete O-glycosylation of mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule.
The coding region of this gene is contained within a single exon.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-100537_GALNT4_Q8N4A0-1_Rabbit.svg, PA5-100537_GALNT4_Q8N4A0-1_Rabbit_PDP.jpeg)