Thermo Fisher Scientific LKB1 Monoclonal Antibody (4H12)
LKB1(STK11) 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, Flow cytometry, ELISA 등에 사용 가능. 인간, 마우스 및 비인간 영장류에 반응하며, 종양억제 단백질 연구에 적합. 비결합형 액상 형태로 제공.
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Thermo Fisher Scientific LKB1 Monoclonal Antibody (4H12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H12 |
| Immunogen | Purified recombinant fragment of human STK11 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11001443 |
Product Specific Information
MA5-15729 targets STK11 in indirect ELISA, FACS, and WB applications and shows reactivity with Human, Mouse, and Non-human primate samples.
The immunogen is a purified recombinant fragment of human STK11 expressed in E. coli.
MA5-15729 detects STK11, which has a predicted molecular weight of approximately 54 kDa.
Target Information
LKB1 (also known as STK11, Serine/threonine-protein kinase STK11) is a tumor suppressor belonging to the serine/threonine kinase family.
LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
It is present in both the cytoplasm and nucleus and translocates to mitochondria during apoptosis.
LKB1 functions as a master upstream protein kinase, regulating AMPK-related kinases as well as AMPK.
Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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