Thermo Fisher Scientific MFSD2A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 3 publications 3 publications

Immunohistochemistry (IHC)

5 µg/mL

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

20 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

An 18 amino acid peptide near the carboxy terminus of human MFSD2A. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MFSD2A,uniProtId:Q8NA29-1,ncbiNodeId:9606,antigenRange:543,antigenLength:543,antigenImageFileName:PA5-21049_MFSD2A_Q8NA29-1_Rabbit.svg,antigenImageFileNamePDP:PA5-21049_MFSD2A_Q8NA29-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152332

Product Specific Information

A suggested positive control is rat lung tissue lysate.

PA5-21049 can be used with blocking peptide PEP-1163.

Target Information

Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.