Thermo Fisher Scientific RPSA Monoclonal Antibody (8G4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
EVMPDLYFYR DPEEIEKEEQ AAAEKAVTKE EFQGEWTAPA PEFTATQPEV ADWSEGVQVP SVPIQQFPTE DWSAQPATED WSAAPTAQAT EWVGATTDWS

Target Information

Laminins are extracellular matrix glycoproteins that form a major component of basement membranes. They are involved in cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Laminin effects are mediated through interactions with cell surface receptors, including integrins and non-integrin laminin-binding proteins.

This gene encodes a high-affinity, non-integrin family laminin receptor 1, also known as:

• 67 kDa laminin receptor
• 37 kDa laminin receptor precursor (37LRP)
• p40 ribosome-associated protein

The amino acid sequence of laminin receptor 1 is highly conserved, indicating an essential biological function. Elevated expression has been observed in colon carcinoma and lung cancer cell lines, correlating with invasive and metastatic phenotypes. Multiple pseudogenes exist, likely derived from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.