Thermo Fisher Scientific Phospho-Chk1 (Ser317) Polyclonal Antibody
Phospho-Chk1 (Ser317) rabbit polyclonal antibody로, CHK1 인산화 상태를 검출하는 데 사용됩니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 액상 형태로 4°C 보관합니다. DNA 손상 반응 연구 및 암 관련 세포주 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphorylated synthetic peptide representing a portion of human Checkpoint Kinase 1 around serine 317 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 plays a key role in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress.
When CHK1 inhibition abrogates the G2 or S checkpoint, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in the G1 phase.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making CHK1 an attractive therapeutic target, especially since approximately 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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