Thermo Fisher Scientific CD23 Recombinant Rabbit Monoclonal Antibody (011)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse CD23/FCER2.

Target Information

CD23 is a 45 kDa glycoprotein present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and is strongly expressed on EBV-transformed B lymphoblasts. It is identical to the low-affinity IgE receptor found on B cells. CD23 expression has been detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lymphomas.

Functionally, CD23 is involved in B cell growth and differentiation and IgE production. A soluble form of CD23 acts as a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.