Thermo Fisher Scientific KCTD13 Monoclonal Antibody (OTI3B12), TrueMAB

Applications

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Target Information

Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the ω-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation.

CYP4F3 exists in two functionally distinct isoforms:

• CYP4F3A: Neutrophil isoform, expressed in neutrophils and myeloid cells, catalyzes microsomal ω-hydroxylation of LTB4. Interacts with CD11b and myeloperoxidase, regulating cellular development in bone marrow.
• CYP4F3B: Liver isoform, catalyzes conversion of arachidonic acid to 20-HETE, a potent activator of PKC, involved in cell proliferation, vascular tone, and natriuresis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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