Thermo Fisher Scientific KCTD13 Monoclonal Antibody (OTI1A4), TrueMAB
인간 KCTD13 단백질을 인식하는 Mouse monoclonal antibody. Western blot에 사용 가능하며, 고순도 Affinity chromatography 정제. PBS/BSA/glycerol buffer에 보관, -20°C에서 안정적. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A4 |
| Immunogen | Full length human recombinant protein of human KCTD13 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytochrome P450 super family proteins are monooxygenases that catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids, and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It contains a conserved heme-binding domain near the C-terminus and catalyzes the ω-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation.
CYP4F3 exists in two functionally distinct isoforms:
- CYP4F3A: Neutrophil isoform expressed in neutrophils and myeloid cells, catalyzes microsomal ω-hydroxylation of LTB4, interacts with CD11b and myeloperoxidase, and regulates cellular development in bone marrow.
- CYP4F3B: Liver isoform that catalyzes conversion of arachidonic acid to 20-HETE, a potent activator of PKC, implicated in cell proliferation, vascular tone, and natriuresis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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