Thermo Fisher Scientific KCTD13 Monoclonal Antibody (OTI1A4), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution tested

Product Specifications

Target Information

Cytochrome P450 super family proteins are monooxygenases that catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids, and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It contains a conserved heme-binding domain near the C-terminus and catalyzes the ω-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation.
CYP4F3 exists in two functionally distinct isoforms:

• CYP4F3A: Neutrophil isoform expressed in neutrophils and myeloid cells, catalyzes microsomal ω-hydroxylation of LTB4, interacts with CD11b and myeloperoxidase, and regulates cellular development in bone marrow.
• CYP4F3B: Liver isoform that catalyzes conversion of arachidonic acid to 20-HETE, a potent activator of PKC, implicated in cell proliferation, vascular tone, and natriuresis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.