Thermo Fisher Scientific RASAL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:10,000–1:25,000

Immunoprecipitation (IP)

• Tested Dilution: 50–100 µL/mg of lysate

Product Specifications

Target Information

The protein encoded by this gene is a member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins, resulting in the inactive GDP-bound form of RAS and thereby allowing control of cellular proliferation and differentiation.
This particular family member contains domains characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to other GAP1 family members, is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.