Thermo Fisher Scientific JAK2 Monoclonal Antibody (OTI2F5), TrueMAB
JAK2 단백질을 인식하는 마우스 단클론 항체로, Western blot 등에 사용 가능. Human 시료에 반응하며, 액상 형태(1 mg/mL)로 제공. PBS, BSA, glycerol 기반 완충액에 보관되며, -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
Tested Application
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 297–596 of human JAK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs can lead to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation, while JAK1 functions as an amplifier. Mutations in JAK2 can cause Budd-Chiari syndrome, polycythemia vera, thrombocythemia 3, myelofibrosis, or acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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