Thermo Fisher Scientific MRGPRX2 Polyclonal Antibody
MRGPRX2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 면역조직화학(IHC) 실험에 적합합니다. Rabbit IgG로 제작되었으며, 비결합형 액상 형태로 제공됩니다. 2–8°C 보관, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 7–18 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 14 amino acid peptide from C-terminus of human MRGPRX2 / MRGX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2551318 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Orangutan, Gibbon (100%)
Gorilla, Monkey (93%)
Target Information
Orphan receptor, probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Cortistatin-14 appears to be a high potency ligand for this receptor. Cortistatin has several biological roles including sleep regulation, locomotor activity, and cortical function.
In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+), but had no effect on basal or forskolin-stimulated cAMP levels, suggesting G(q)-coupling.
Expression is limited to both peripheral and central nervous systems, with highest levels in dorsal root ganglion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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