Thermo Fisher Scientific MRGPRX2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MRGPRX2 for IHC (Paraffin) applications. High specificity validated by BLAST analysis. Suitable for detecting orphan receptor involved in nociceptive neuron function. Supplied as liquid, 1 mg/mL, stored at 4°C...
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- PA533951
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 10–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 14 amino acid peptide from 2nd extracellular domain of human MRGPRX2 / MRGX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551319 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Orangutan, Monkey: 100%
- Chimpanzee, Gorilla, Gibbon, Marmoset: 86%
Target Information
MRGPRX2 is an orphan receptor likely involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain.
Cortistatin-14 acts as a high potency ligand for this receptor. Cortistatin has several biological functions, including roles in sleep regulation, locomotor activity, and cortical function.
In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca²⁺ were observed, but no effect was seen on basal or forskolin-stimulated cAMP levels, suggesting G(q)-coupled signaling.
Expression is limited, both peripherally and within the central nervous system, with highest levels in the dorsal root ganglion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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