Thermo Fisher Scientific MRGPRX2 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 10–20 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human, Orangutan, Monkey: 100%
• Chimpanzee, Gorilla, Gibbon, Marmoset: 86%

Target Information

MRGPRX2 is an orphan receptor likely involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain.
Cortistatin-14 acts as a high potency ligand for this receptor. Cortistatin has several biological functions, including roles in sleep regulation, locomotor activity, and cortical function.
In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca²⁺ were observed, but no effect was seen on basal or forskolin-stimulated cAMP levels, suggesting G(q)-coupled signaling.
Expression is limited, both peripherally and within the central nervous system, with highest levels in the dorsal root ganglion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.