Thermo Fisher Scientific Aurora B Polyclonal Antibody
Aurora B 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 최적화되어 있으며 인간 시료에 반응. 고순도 액상 형태로 제공되며 안정적인 TBS 버퍼에 보관. 세포 분열 및 염색체 정렬 연구에 적합.
- 카탈로그번호
- PA5142225
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Aurora B Polyclonal Antibody
Applications
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence YKELQKSCTFDEQ (aa 163–175) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932879 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The Chromosomal Passenger Complex (CPC) includes three non-enzymatic subunits: inner centromere protein (INCENP), survivin, and borealin. These determine the activity, localization, stability, and substrate specificity of Aurora B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora B. The quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3.
Aurora B is overexpressed in several tumors, including primary breast and colon tumor samples. Its expression appears linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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