Thermo Fisher Scientific PTPN11 Monoclonal Antibody (OTI3F2), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The PTPN11 gene encodes a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, which mediate phospho-tyrosine binding and substrate interactions.
It is widely expressed across tissues and plays a regulatory role in signaling events critical for mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.