Thermo Fisher Scientific PTPN11 Monoclonal Antibody (OTI3F2), TrueMAB
PTPN11 단백질을 표적하는 마우스 단일클론 항체로, Western blot과 유세포분석에 적합. 인간 및 개 반응성. 무보존제, 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도 유지. 세포 신호 조절 및 암 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F2 |
| Immunogen | Full-length human recombinant protein of human PTPN11 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The PTPN11 gene encodes a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, which mediate phospho-tyrosine binding and substrate interactions.
It is widely expressed across tissues and plays a regulatory role in signaling events critical for mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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