Thermo Fisher Scientific PLA2R1 Monoclonal Antibody (12-6-5)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

12-6-5

Immunogen

Human PLA2R1 extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3) amino acids 20-663 Recombinant protein expressed in HEK 293-EBNA-1 cells if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PLA2R1,uniProtId:Q13018-1,ncbiNodeId:9606,antigenRange:20-663,antigenLength:1463,antigenImageFileName:MA1-212_PLA2R1_Q13018-1_House_mouse.svg,antigenImageFileNamePDP:MA1-212_PLA2R1_Q13018-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.2-7.4

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2688343

Product Specific Information

The immunogen is the Human PLA2R1 extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3) amino acids 20-663 Recombinant protein expressed in HEK 293-EBNA-1 cells

Target Information

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.