Thermo Fisher Scientific PLA2R1 Monoclonal Antibody (12-6-5)
인간 PLA2R1 단백질을 인식하는 Mouse IgG2b 단일클론 항체. IHC(P)에서 1:250 희석으로 검증됨. 단백질 G 정제, 액상 형태, PBS 버퍼에 0.05% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12-6-5 |
| Immunogen | Human PLA2R1 extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3), amino acids 20–663. Recombinant protein expressed in HEK 293-EBNA-1 cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS, pH 7.2–7.4 |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2688343 |
Product Specific Information
The immunogen is the Human PLA2R1 extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3), amino acids 20–663. Recombinant protein expressed in HEK 293-EBNA-1 cells.
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2.
Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as:
- Activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation
- Production of lipid mediators
- Selective release of arachidonic acid in bone marrow-derived mast cells
- In neutrophils, activation of p38 MAPK to stimulate elastase release and cell adhesion
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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