Thermo Fisher Scientific PNPLA2 Polyclonal Antibody, MaxPab
PNPLA2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 시료에 반응하며 Western blot에 적합. 액상 형태로 제공되며, PBS 버퍼에 보존제 없이 −20°C에서 보관. 지방분해 효소 연구 및 대사 관련 연구용.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | PNPLA2 (NP_065109.1, 1–504 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGVCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQGYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVPEEDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALPGWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQLAGPAPLLSTPAPEARPVIGALGL
Target Information
Lipolytic enzymes are essential for mobilizing fatty acids from triglyceride stores in adipose tissue. Dysfunctional lipolysis affects energy homeostasis and may contribute to obesity and insulin resistance. Hormone-sensitive lipase (HSL) was previously known as the main enzyme for triglyceride hydrolysis, but adipose triglyceride lipase (ATGL) has been identified as initiating triglyceride breakdown. ATGL is highly expressed in adipose tissue of mice and humans, specifically hydrolyzing triacylglycerol and associating with lipid droplets. Inhibition of ATGL decreases total adipose acyl-hydrolase activity, showing that ATGL and HSL work together to catabolize stored triglycerides in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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