Thermo Fisher Scientific MAGE-1 (Target for Cancer Immunotherapy) Monoclonal Antibody (MZ2E/838)
MAGE-1 단백질을 표적으로 하는 단클론 항체로, 암 면역치료 연구용에 적합. 다양한 인간 종양에서 MAGE-1 발현 검출에 사용. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 단백질 A/G 정제 및 PBS 완충액에 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MZ2E/838 |
| Immunogen | Recombinant human MAGEA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human malignant neoplasms carry rejection antigens recognized by patients' autologous, tumor-directed, specific cytolytic CD8+ T lymphocyte clones (CTLs). An important group of these antigens is encoded by the MAGE family of genes, including melanoma-associated antigens (MAAs). MAGE-1 is expressed in a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) but not in normal tissues. Therefore, the encoded antigen may serve as a marker for early detection and a target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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