Thermo Fisher Scientific MAGE-1 (Target for Cancer Immunotherapy) Monoclonal Antibody (MZ2E/838)
암 면역치료 타겟인 MAGE-1 단백질을 인식하는 단클론 항체. 인간 종 특이적이며 다양한 종양 조직에서 발현. 면역조직화학, 유세포분석 등 다중 응용 가능. 연구용으로 고순도 Protein A/G 정제 및 PBS 저장.
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Thermo Fisher Scientific MAGE-1 (Target for Cancer Immunotherapy) Monoclonal Antibody (MZ2E/838)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MZ2E/838 |
| Immunogen | Recombinant human MAGEA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human malignant neoplasms carry rejection antigens recognized by autologous, tumor-directed, and specific cytolytic CD8+ T lymphocyte clones (CTL). An important group of antigens is encoded by the MAGE family of genes, identified as melanoma-associated antigens (MAAs).
MAGE-1 is expressed in a significant proportion of human neoplasms of various histological types—melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas—but not in normal tissues. Therefore, the encoded antigen may serve as a marker for early detection and as a target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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