Thermo Fisher Scientific PARP12 Polyclonal Antibody
Rabbit polyclonal antibody against human PARP12 for WB and ELISA applications. Reacts with human, mouse, and rat samples. Affinity purified, unconjugated, liquid form with 1.84 mg/mL concentration. Stored at -20°C in PBS with glycerol; suitable for nuc...
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Thermo Fisher Scientific PARP12 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 462–701 of human PARP12 (NP_0735871) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.84 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805758 |
Product Specific Information
Immunogen sequence:
YVSPQDVTTM QTCNTKFPGP KSIPDYWDSS ALPDPGFQKI TLSSSSEEYQ KVWNLFNRTL PFYFVQKIER VQNLALWEVY QWQKGQMQKQ NGGKAVDERQ LFHGTSAIFV DAICQQNFDW RVCGVHGTSY GKGSYFARDA AYSHHYSKSD TQTHTMFLAR VLVGEFVRGN ASFVRPPAKE GWSNAFYDSC VNSVSDPSIF VIFEKHQVYP EYVIQYTTSS KPSVTPSILL ALGSLFSSRQ
Positive Samples: HT-29, HeLa, Mouse brain, Mouse liver, Mouse pancreas, Rat brain
Cellular Location: Nucleus
Target Information
Poly(ADP-ribosyl)ation is a DNA-damage-dependent post-translational modification of histones and other nuclear proteins, contributing to survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) form a family of 18 proteins with conserved catalytic domains. PARP-1 and PARP-2 are activated by DNA strand breaks. Novel PARPs extend the field of poly(ADP-ribosyl)ation to various aspects of cell biology, including proliferation and death. These members share common partners and localizations, suggesting fine regulation of this modification.
Safety Information
⚠ WARNING: This product contains mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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