Thermo Fisher Scientific Protein C Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human Coagulation Protein C (NP_0003031) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Protein C,uniProtId:P04070-1,ncbiNodeId:9606,antigenRange:43-300,antigenLength:461,antigenImageFileName:PA5-89751_Protein_C_P04070-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89751_Protein_C_P04070-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.98 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805759

Product Specific Information

Positive Samples: ES-2; Cellular Location: Endoplasmic reticulum, Golgi apparatus

Immunogen sequence: ANSFLEELRH SSLERECIEE ICDFEEAKEI FQNVDDTLAF WSKHVDGDQC LVLPLEHPCA SLCCGHGTCI DGIGSFSCDC RSGWEGRFCQ REVSFLNCSL DNGGCTHYCL EEVGWRRCSC APGYKLGDDL LQCHPAVKFP CGRPWKRMEK KRSHLKRDTE DQEDQVDPRL IDGKMTRRGD SPWQVVLLDS KKKLACGAVL IHPSWVLTAA HCMDESKKLL VRLGEYDLRR WEKWELDLDI KEVFVHPNYS KSTTDNDI

Target Information

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 µg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.