Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI7D1), TrueMAB
RYBP 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 최적화됨. 인간 단백질에 반응하며, 고순도 친화 크로마토그래피 정제. 액상 형태로 PBS/BSA/glycerol 버퍼에 보존되며 -20°C에서 안정적 저장 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7D1 |
| Immunogen | Full length human recombinant protein of human RYBP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, which maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. This complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, leading to heritable changes in chromatin expressibility.
RYBP is involved in monoubiquitination of histone H2A Lys-119 on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. It may stimulate histone ubiquitination by recruiting the complex to target sites and inhibit ubiquitination and degradation of TP53, thus regulating transcription of TP53 target genes.
Additionally, RYBP may regulate ubiquitin-mediated proteasomal degradation of proteins such as FANK1 to control apoptosis and act as a transcriptional repressor of E4TF1 activity. It may bind DNA and play a role in repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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