Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI1B2), TrueMAB
RYBP 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간 시료에 반응하며, 고순도 친화 크로마토그래피 정제. 연구용으로 사용되며, -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Full length human recombinant protein of human RYBP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex required to maintain transcriptional repression of genes such as Hox during development. This complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, which alters chromatin expressibility.
RYBP is involved in X chromosome silencing in females and may recruit the PRC1-like complex to target sites. It inhibits TP53 ubiquitination and degradation, regulating transcription of TP53 target genes. It may also control proteasomal degradation of proteins such as FANK1 to regulate apoptosis and repress transcriptional activity of E4TF1.
RYBP may play a role in tumor growth repression and metastasis inhibition in breast cancer through down-regulation of SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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