Thermo Fisher Scientific PICK1 Monoclonal Antibody (4G1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000

-

Flow Cytometry (Flow)

1:100

-

Immunoprecipitation (IP)

1:10-1:50

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

4G1

Immunogen

Recombinant protein within N-terminal human PICK1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PICK1,uniProtId:Q9NRD5-1,ncbiNodeId:9606,antigenRange:1,antigenLength:415,antigenImageFileName:BSM-54393R_PICK1_Q9NRD5-1_Rabbit.svg,antigenImageFileNamePDP:BSM-54393R_PICK1_Q9NRD5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

Target Information

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.