Thermo Fisher Scientific PKC zeta Polyclonal Antibody
PKC zeta 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)와 ELISA에 사용 가능. 인간 PRKCZ의 1st cytoplasmic domain 유래 펩타이드를 면역원으로 제작. 세포 성장, 분화, 유전자 발현 연구에 활용. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 1st cytoplasmic domain of human PRKCZ / PKC-Zeta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2550450 |
Product Specific Information
- In IHC applications, antigen retrieval using Proteinase K treatment is recommended.
- Percent identity with other species by BLAST analysis:
- Human, Gorilla (100%)
- Monkey, Marmoset (94%)
- Dog, Panda, Horse (89%)
- Rat, Elephant (83%)
Target Information
The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC zeta plays a key regulatory role in various cellular functions including cell growth and differentiation, gene expression, hormone secretion, and membrane function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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