Thermo Fisher Scientific PKC zeta Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human, Gorilla: 100%
• Monkey: 95%
• Marmoset, Mouse, Rat, Rabbit: 89%

For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.

PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion, and membrane function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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