Thermo Fisher Scientific PKC zeta Polyclonal Antibody
Rabbit polyclonal antibody targeting human PKC zeta (PRKCZ). Validated for IHC(P) and ELISA applications. High specificity with cross-species reactivity. Purified via antigen affinity chromatography, supplied as liquid form at 1 mg/mL concentration. Fo...
- 카탈로그번호
- PA532990
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from near N-terminus of human PRKCZ / PKC-Zeta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550451 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla: 100%
- Monkey: 95%
- Marmoset, Mouse, Rat, Rabbit: 89%
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion, and membrane function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA5-32990_PKC_zeta_Q05513-1_Rabbit_PDP.jpeg, PA5-32990_PKC_zeta_Q05513-1_Rabbit.svg)
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