Thermo Fisher Scientific SPTLC2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse liver
• Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (80%), Chicken (84%), Bovine (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis, consisting of two different subunits. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor.
SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. It is catalytically active but requires SPT1 for stabilization and anchoring to the endoplasmic reticulum.
Mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from loss of SPT activity and accumulation of neurotoxic sphingoid metabolites such as 1-deoxy-sphinganine.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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