Thermo Fisher Scientific AP3B2 Polyclonal Antibody

Thermo Fisher Scientific AP3B2 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500
Publications: -

Product Specifications

Product Specific Information

PA1-1067 detects beta NAP from human, rat, and mouse samples.
It has been successfully used in Western blot applications.
By Western blot, this antibody detects a ~119–130 kDa protein representing beta NAP from brain samples.
The PA1-1067 immunogen is a mixture of synthetic peptides corresponding to residues L(260) L E E N (A/P) E K A F Y G S E E(274) of human and mouse beta NAP.
The immunizing peptides (Cat. # PEP-294) are available for purchase for use in neutralization controls.

Target Information

The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2), and a small adaptin (APS1 or AP3S2).
The complex is associated with the Golgi region as well as more peripheral structures.
It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Unlike the homologous AP3B1, AP3B2-containing AP3 complexes are preferentially targeted to neuronal processes, and mice deficient in AP3B2 displayed compromised synaptic zinc stores.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.